Tottenham Hotspur have the chance to exert psychological pressure on Premier League leaders Chelsea when they open the weekend programme at home to Watford on Saturday.
Following is a match by match look at the English Premier League's weekend fixtures:
England's right-back Kieran Trippier is one of the World Cup's top performers.
Only one point separates the two sides with Chelsea on 31 and City on 30 but Antonio Conte's impact at Stamford Bridge appears greater than his City counterpart Pep Guardiola's at the Etihad.
Barcelona look well set to wrap up the La Liga title.
Chelsea brought a whole new dimension to the Premier League title race when they handed Manchester City their first defeat of the season on Saturday to leave Mohamed Salah-inspired Liverpool as the new leaders.
IMAGES from the English Premier League matches played on Tuesday
Manchester United striker Romelu Lukaku defended Jose Mourinho's confrontational style of management, saying that the Portuguese deserves respect for not hiding his true feelings like several Premier League bosses.
Mohamed Salah was inevitably on the scoresheet as Liverpool took full advantage of the inactivity of their top-four rivals to thrash West Ham United 4-1 at Anfield and provisionally move into second in the Premier League.
News of all that's transpired on and off the football field
Harry Kane's magical season continued on Saturday as he celebrated his first senior England call-up with his first Premier League hat-trick.
A summary of the results of the major European football league matches on the weekend.
Manchester City thrashed Southampton 6-1 to remain top of the Premier League.
Strikers Marcus Rashford and Daniel Sturridge made Roy Hodgson's final 23-man England squad for Euro 2016 on Tuesday but winger Andros Townsend and midfielders Danny Drinkwater and Fabian Delph were left out. England are taking five forwards to the 24-team tournament in France, which starts on June 10, with Sturridge selected despite doubts over a calf problem. The injury had forced the Liverpool striker to miss England's last two friendly matches, including Friday's win over Australia in Sunderland. The 18-year-old Rashford, who signed a new long-term deal with Manchester United on Monday, became the youngest player to score on his England debut in the 2-1 win at the Stadium of Light. He scored that goal 138 seconds into what was only his 19th professional match, marking him out as one of the brightest emerging prospects and winning plaudits from Hodgson.
Tottenham Hotspur's status as Premier League title chasers was seriously harmed on Saturday as they fell to a first defeat in seven league games, losing the lead to go down 3-1 at home to Wolverhampton Wanderers.
Manchester United manager Jose Mourinho said full back Luke Shaw used "his body with my brain" during his side's 1-1 draw with Everton on Tuesday and has urged the England international to develop a better understanding of the game.
Cardiff had lost six of their previous seven games but, knowing that anything but a victory would probably end their survival hopes after one season in the top flight, overcame a strong Brighton start to play with growing confidence and fully deserved their victory.
English football clubs splurged on the final day of the transfer window, laying out 210 million pounds to take total gross spending to a record-high 1.4 billion pounds as the Premier League again flexed its unrivalled financial muscles.
The visitors got off to the perfect start when a mix up at the back saw Riyad Mahrez square for Jamie Vardy to tap into an open goal in front of the Kop in the third minute. Liverpool looked for an immediate riposte, but Salah missed two gilt-edged opportunities before Sadio Mane saw an effort disallowed for offside as Juergen Klopp's men grew frustrated.
News of all that's transpired on and off the football field
Manchester City soared above the fog swirling round the Etihad Stadium to demolish Tottenham Hotspur 4-1 and leave the rest of the Premier League peering into the distance in search of Pep Guardiola's record-breaking team on Saturday.
News of all that transpired on and off the field.
Arsenal travel across town to a vengeful Chelsea on Saturday knowing that another depressing defeat at Stamford Bridge would see their Premier League title hopes swept away with the lunchtime leftovers.
France international striker Antoine Griezmann has reached an agreement with Manchester United over a transfer from Atletico Madrid at the end of the season, Yahoo Sport has reported.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
'Everton can confirm that Wayne Rooney has rejoined the club from Manchester United on a two-year deal for an undisclosed fee'
There may be little glamour in being a mid-table Premier League team but this season suggests that those clubs who become bored with such an existence can find the alternative is far worse.
News of all that's transpired on and off the football field
Arsenal coach Arteta has said that Granit Xhaka will stay at the London club while United have new headaches with injuries to Paul Pogba and Scott McTominay.
All eyes will be on Manchester United manager Louis van Gaal when he takes his team to Derby County for an FA Cup fourth-round tie on Friday with the fans' boos from their home defeat by Southampton still ringing in his ears.
Saturday's clash between Manchester United and Tottenham Hotspur at Old Trafford is already shaping up as an early-season eliminator to challenge runaway leaders Manchester City for the Premier League title.
IMAGES from the English Premier League matches played on Tuesday
Manchester City stayed ahead of age-old local rivals Manchester United at the top of the Premier League on Saturday with a deserved 1-0 win away to champions Chelsea.
Leicester City's Premier League title defence got off to a terrible start as they were beaten 2-1 at promoted Hull City, who shrugged off an injury crisis to shock the champions on the opening day of the new season on Saturday
Pogba suffered the injury in United's 3-0 Champions League win over Basel this month.
A summary of sports events and sports persons, who made news on Tuesday
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
London clubs' erratic start to the Premier League season improved with victories for Chelsea, Tottenham Hotspur and Arsenal on Saturday but Manchester sides continued to make the running, with City and United the top two.
Manchester United's struggle to achieve a top-four finish continued on Tuesday as Zlatan Ibrahimovic came to their rescue with an added time penalty to salvage a 1-1 draw against Everton in their Premier League clash at Old Trafford.
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